Research Publications

Allison A B

TITLE:                    Intususception in infancy and childhood: an analysis of 69 cases.

AUTHORS:           Mangete ED , Allison AB (1994)



A retrospective study of 69 cases of intususception treated at the University of Port Harcourt Teaching Hospital, Port Harcourt in the past seven years from October, 1985 to September, 1992 is presented. The diagnosis was made clinically and confirmed at operation. Fifty (72.5%) of the 69 patients belonged to the three to nine month age group. There was a male preponderance; male to female ratio 3.6:1. The classic triad of abdominal pain, rectal bleeding and abdominal mass occurred in only 11 patients (15.9%). All 69 patients had laparotomy as reduction using barium enema was not attempted. Of the 35 patients who required resection 27 (77.1%) had gangrenous bowel and 2 (2.8%) had perforation as well. Mortality was 11.6%. The high mortality rate appears to be related to the long interval between onset of symptoms and commencement of definitive treatment.




TITLE:                    Oxidative stress following traumatic brain injury: enhancement of endogenous antioxidant defence systems and the promise of improved outcome

AUTHORS:           P.O Eghwrudjakpor, A.B Allison (2010)



Background: Management of brain injury can pose enormous challenges to the health team. There are many studies aimed at discovering or developing pharmacotherapeutic agents targeted at improving outcome of head-injured patients. This paper reviews the role of oxidative stress in

neuronal loss following traumatic brain injury and presents experimental and clinical evidence of the role  of  exogenous antioxidants as neuroprotectants. Method: We reviewed published literature on reactive oxygen species and their role in experimental and clinical brain injuries in journals and the Internet using Yahoo and Google search engines. Results: Traumatic brain injury causes massive production of reactive oxygen species with resultant oxidative stress. In experimental brain injury, exogenous antioxidants are useful in limiting oxidative damage. Results with clinical brain injury are however more varied. Conclusion: Oxidative stress due to excessive generation of reactive oxygen species with consequent impai rment of endogenous antioxidant defence mechanisms plays significant role in the secondary events leading to neuronal death. Enhancement of the defence mechanisms through the use of exogenous antioxidants may be neuroprotective, especially the agents can penetrate cell membranes, are able to cross the blood-brain barrier and if they are administered within the neuroprotective time window.

Keywords: Antioxidants; Oxidative stress; Outcome; Pathophysiology; Reactive oxygen species; Traumatic brain injury



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